Motivation to choose the night course in engineering

This paper presents the research about the motivation of students to choose night period for enrolling engineering programs. The survey was conducted in two different countries of different continents but united by the language and common history. The results are showed in details and some conclusions about the motivations are presented in accordance with the results taking into account the geography, the economic and historical moments of both countries involved in the researchThis work is supported by national funds through FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019/2019 and the Project UID/CTM/002642C2T – Centro de Ciência e Tecnologia Têxtil

Rethinking engineering education

The Professional of today needs to acquire a dynamic ability to absorb information, adjust to organizational goals, and navigate in a complex work environment. For this reason, a classic approach seems to be more useful for the demands of today's job market. It is at least interesting to notice, that the classic approach is being neglected, at a time when its product might be more interesting than ever. The Engineering Education Team of COPEC – Science and Education Research Council has designed a program that is knowledge centered and specially challenging, which integrates classical engineering approaches and real experience in order to achieve a high level of engineers ready to perform as professionals or researchers. It aims to form the Engineer – a professional that is capable to learn for life and be creative in many ways.This work is financed by FEDER funds through the Competitivity Factors Operational Programme – COMPETE: POCI-01-0145-FEDER-007043 and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01-0145-FEDER-007136 and project UID/CEC/00319/2013.info:eu-repo/semantics/publishedVersio

International experiences and the implications for the success of engineering programs

The working midst has become challenging due to the multicultural environment and the need of skills such as cultural understanding, are very important in the formation of an engineer. It has been like this for many years however, now more than ever. So, for engineering schools, internationalization has become, on top of others, another demand for the accomplishment of a good program. It became necessary to provide international academic experience for the students. For this reason, internationalization is now a strategy to raise the quality of courses and as another result of these efforts, to raise the engineering students’ retention rate along the program. The goal of this paper is to present and discuss the internationalization process of a University’s engineering school, with the objective of making the program more attractive and promoting the double diploma in order to higher the quality of the programs.(undefined)info:eu-repo/semantics/publishedVersio

Percutaneous treatment of mitral regurgitation by MitraClipTM: report on the first two procedures in Brazil

AbstractThe MitraClipTM system has been recently approved for clinical use in Brazil for percutaneous treatment of mitral valve regurgitation. This device is based on the Alfieri surgical procedure, creating a double orifice by bringing together the central segments of the two mitral valve cusps. This report describes the first two procedures performed in Brazil using this device. Two female patients considered to be at high surgical risk due to advanced age and presence of comorbidities were treated, with degenerative mitral regurgitation due to prolapse/flail, associated with chordae tendineae rupture. In both cases, significant mitral regurgitation intensity reduction was obtained using the MitraClipTM, demonstrating the great potential of this innovative technology for the percutaneous treatment of mitral valve regurgitation

Global experiences for engineering programs

This paper has the goal to present and discusses the internationalization process of a university starting by the engineering programs that the engineering school offers. The objective is to make it more attractive and promote the double diploma in order to higher the quality of the programs.info:eu-repo/semantics/publishedVersio

Functional Induction of the Cystine-Glutamate Exchanger System Xc- Activity in SH-SY5Y Cells by Unconjugated Bilirubin

We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na+ -independent cystine∶glutamate exchanger System Xc− (SLC7A11 and SLC3A2 genes). In this study we demonstrate that SH-SY5Y cells treated with UCB showed a higher cystine uptake due to a significant and specific increase in the activity of System Xc−, without the contribution of the others two cystine transporters (XAG− and GGT) reported in neurons. The total intracellular glutathione content was 2 folds higher in the cells exposed to bilirubin as compared to controls, suggesting that the internalized cystine is used for gluthathione synthesis. Interestingly, these cells were significantly less sensitive to an oxidative insult induced by hydrogen peroxide. If System Xc− is silenced the protection is lost. In conclusion, these results suggest that bilirubin can modulate the gluthathione levels in neuroblastoma cells through the induction of the System Xc−, and this renders the cell less prone to oxidative damage

Factors Associated with Tuberculosis Treatment Default in an Endemic Area of the Brazilian Amazon: A Case Control-Study

SETTING: Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source, increased mortality, increased relapse rates and facilitates the development of resistant strains. OBJECTIVE: This study analyzed tuberculosis treatment default determinants in the Amazonas State to contribute in planning appropriate control interventions. DESIGN: Observational study with a retrospective cohort using Brazilian Disease Notification System data from 2005 to 2010. A nested case control study design was used. Patients defaulting from treatment were considered as 'cases' and those completing treatment as 'controls'. In the analysis, 11,312 tuberculosis patients were included, 1,584 cases and 9,728 controls. RESULTS: Treatment default was observed to be associated to previous default (aOR 3.20; p<0.001), HIV positivity (aOR 1.62; p<0.001), alcoholism (aOR 1.51; p<0.001), low education level (aOR 1.35; p<0.001) and other co-morbidities (aOR 1.31; p = 0.05). Older patients (aOR 0.98; p = 0.001) and DOT (aOR 0,72; p<0.01) were considered as protective factor for default. CONCLUSIONS: Associated factors should be considered in addressing care and policy actions to tuberculosis control. Information on disease and treatment should be intensified and appropriate to the level of education of the population, in order to promote adherence to treatment and counter the spread of multidrug resistance to anti-TB drugs

Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by Bilirubin at the Blood-CSF and Blood-Brain Barriers in the Gunn Rat

Accumulation of unconjugated bilirubin (UCB) in the brain causes bilirubin encephalopathy. Pgp (ABCb1) and Mrp1 (ABCc1), highly expressed in the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) respectively, may modulate the accumulation of UCB in brain. We examined the effect of prolonged exposure to elevated concentrations of UCB on expression of the two transporters in homozygous, jaundiced (jj) Gunn rats compared to heterozygous, not jaundiced (Jj) littermates at different developmental stages (2, 9, 17 and 60 days after birth). BBB Pgp protein expression was low in both jj and Jj pups at 9 days (about 16–27% of adult values), despite the up-regulation in jj animals (2 and 1.3 fold higher than age matched Jj animals at P9 and P17–P60, respectively); Mrp1 protein expression was barely detectable. Conversely, at the BCSFB Mrp1 protein expression was rather high (60–70% of the adult values) in both jj and Jj at P2, but was markedly (50%) down-regulated in jj pups starting at P9, particularly in the 4th ventricle choroid plexuses: Pgp was almost undetectable. The Mrp1 protein down regulation was accompanied by a modest up-regulation of mRNA, suggesting a translational rather than a transcriptional inhibition. In vitro exposure of choroid plexus epithelial cells obtained from normal rats to UCB, also resulted in a down-regulation of Mrp1 protein. These data suggest that down-regulation of Mrp1 protein at the BSCFB, resulting from a direct effect of UCB on epithelial cells, may impact the Mrp1-mediated neuroprotective functions of the blood-cerebrospinal fluid barrier and actually potentiate UCB neurotoxicity